Many patients choose compounded or generic GLP-1s, often through telehealth or peptide vendors, primarily for affordability or to allow for microdosing due to sensitivity. Patients report experiencing similar benefits like reduced food noise, weight loss, and reduced inflammation, akin to brand-name medications. However, they also encounter similar side effects, such as nausea, gastrointestinal issues, and anxiety, sometimes requiring dose adjustments.
"I started on generic semaglutide a week and a half ago, so I have taken 2x0.25 doses at this point. I have not noticed significant craving reduction, appetite suppression, or weight loss so far. The only effects I’ve experienced have been very minor reduction in cravings and some diarrhea and gas a day or two after my injections."
Patient · Generic Semaglutide, 1 week
"This has been life changing for my menopause journey. Been micrdosing for a full year at 1-1.5 mgs. I lost 10 lbs but that was not my goal for trying it and since I was told 2.5 was a starting dose for weight loss, I was shocked I had that side effect. Will be on it indefinitely. I went with telehealth initially but found it cheaper using a peptide vendor. If you are comfortable with research, that’s the way to go. The inflammatory benefits are unbelievable. Best of luck to you!"
Patient · GLP-1 (microdosing), 1 year
"I'm only 2 shots in (and not even taking my starter dose yet) and this has been one of the hardest things I think I've ever done. I'm on compounded tirzepatide through my doctor for pmos (pcos), elevated a1c and elevated fasting glucose. The side effects have not been horrible, but because I have sensory processing disorder, I feel everything multiplied."
Patient · Compounded Tirzepatide, 2 shots
"Micro dosing Semaglutide due to sensitivity. Would Trizepitide be better? I started in Semaglutide (SG) back in August on a 3 month supply. I started with the initial starting dose, but felt horrible and didn’t eat…couldn’t eat. The thought of food was 🤢 inducing. I cut back my dosage and modified the schedule until I found a good level for my body to respond to and not make me feel horrible daily. I am currently on 0.15mg (6u) about every 10 days."
Patient · Microdosing Semaglutide, 10 months
The safety and efficacy of compounded medications can vary due to a lack of FDA oversight, and it's essential to discuss the source and potential risks with a healthcare provider.
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