Many patients initially experience nausea, particularly in the first few weeks or when increasing their dose. For a significant number of these individuals, the nausea is mild to moderate and tends to lessen or become more manageable as their body adjusts to the medication, often after a few doses. However, some patients may continue to experience occasional or more significant nausea, especially if they are sensitive to dose increases, and a small number find it persistently challenging or intolerable.
Nausea can be a common side effect of GLP-1 medications; if it becomes severe, persistent, or accompanied by other concerning symptoms, it's important to contact your healthcare provider.
"Hi there, I am just embarking on my 3rd week. I have only had two doses of .25 thus far and minimal side effects; some nausea, heartburn, indigestion, etc but all very much manageable."
Patient · Ozempic, 3 weeks
"Will there always be GI side effects? I have only just taken my 2nd dose this week, but so far I have noted very minimal GI affects. Only maybe some slight heartburn and nausea, but as far as everything else goes, without being TMI, everything is running as usual lol!"
Patient · Ozempic, 2 weeks
"It stinks to have 1-3 days where I’m basically immobile and going back to the ER scares me but it does seem to get better for people after a few doses."
Patient · Zepbound, unknown duration
"I just cannot seem to tolerate any GLP-1s and I’m frustrated. I’ve now tried Ozempic, Mounjaro, and Zepbound. All causing the same response on day 3. Awful, don’t make plans diarrhea that do not respond to Imodium or Pepto, gag-worthy sulphur burps, and even vomiting on the Ozempic."
Patient · Semaglutide, unknown duration
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